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FA2H Antibody (PA5-100512) in IHC (P)
Immunohistochemistry analysis of FA2H in mouse liver tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with FA2H polyclonal antibody (Product # PA5-100512) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-100512
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human FA2H(Accession Q7L5A8), corresponding to amino acid residues L33-G83.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850021
产品详细信息
Antibody detects endogenous levels of total FA2H.
靶标信息
FA2H is a protein that catalyzes the synthesis of 2-hydroxysphingolipids, a subset of sphingolipids that contain 2-hydroxy fatty acids. Sphingolipids play roles in many cellular processes and their structural diversity arises from modification of the hydrophobic ceramide moiety, such as by 2-hydroxylation of the N-acyl chain, and the existence of many different head groups.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Fatty acid 2-hydroxylase; Fatty acid alpha-hydroxylase; fatty acid hydroxylase domain containing 1; Fatty acid hydroxylase domain-containing protein 1; FLJ25287; spastic paraplegia 35 (autosomal recessive); WD repeat domain 59
基因别名: FA2H; FAAH; FAH1; FAXDC1; G630055L08Rik; RGD1310347; SCS7; SPG35; Wdr59
UniProt ID: (Human) Q7L5A8, (Rat) Q2LAM0, (Mouse) Q5MPP0
Entrez Gene ID: (Human) 79152, (Rat) 307855, (Mouse) 338521
iron ion binding
heme binding
fatty acid alpha-hydroxylase activity
N-ethylmaleimide reductase activity
oxidoreductase activity
reduced coenzyme F420 dehydrogenase activity
sulfur oxygenase reductase activity
malolactic enzyme activity
NADPH:sulfur oxidoreductase activity
metal ion binding
epoxyqueuosine reductase activity
hydroxylase
sebaceous gland cell differentiation
fatty acid metabolic process
fatty acid biosynthetic process
sphingolipid biosynthetic process
lipid modification
central nervous system myelin maintenance
peripheral nervous system myelin maintenance
regulation of cell proliferation
regulation of hair cycle
oxidation-reduction process
sphingolipid metabolic process
lipid metabolic process
transport
