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The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; Mediator of receptor induced toxicity; MGC8528; protein FADD
基因别名: Fadd; Mort1; Mort1/FADD
UniProt ID: (Mouse) Q61160
Entrez Gene ID: (Mouse) 14082