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Invitrogen
FAM122A Monoclonal Antibody (3E9)
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FAM122A Antibody (MA5-24510) in WB
Western blot analysis of F122A / FAM122A in transfected 293T cell line. Lane 1: FAM122A transfected lysate (Predicted MW: 30.5 KDa). Lane 2: Non-transfected lysate. Samples were probed using a Mouse Monoclonal F122A / FAM122A (3E9) Antibody (Product # MA5-24510).
产品信息
MA5-24510
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
C. elegans
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3E9
抗原
FAM122A (NP_612206.3, 1 a.a. ~ 287 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Peptide Sequence: MAQEKMELDL ELPPGTGGSP AEGGGSGGGG GLRRSNSAPL IHGLSDTSPV FQAEAPSARR NSTTFPSRHG LLLPASPVRM HSSRLHQIKQ EEGMDLINRE TVHEREVQTA MQISHSWEES FSLSDNDVEK SASPKRIDFI PVSPAPSPTR GIGKQCFSPS LQSFVSSNGL PPSPIPSPTT RFTTRRSQSP INCIRPSVLG PLKRKCEMET EYQPKRFFQG ITNMLSSDVA QLSDPGVCVS SDTLDGNSSS AGSSCNSPAK VSTTTDSPVS PAQAASPFIP LDELSSK
靶标信息
Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin- mediated proteolysis of WEE1, thereby releasing G2/M checkpoint.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: PABIR family member 1; PPP2R1A-PPP2R2A-interacting phosphatase regulator 1
基因别名: C9orf42; FAM122A; PABIR1
UniProt ID: (Human) Q96E09
Entrez Gene ID: (Human) 116224
