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Invitrogen
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Immunogen sequence: EGKKAAQRHET LTSLNLEKKA RLKEEAAMKA K
Highest antigen sequence identity to the following orthologs - mouse 88%, rat 88%.
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: E2-induced gene 5 protein; f162; family with sequence similarity 162, member A; Growth and transformation-dependent protein; HGTD-P; HIF-1 alpha-responsive proapoptotic molecule; Protein FAM162A
基因别名: C3orf28; DC16; E2IG5; FAM162A; FWP001; HGTD-P
UniProt ID: (Human) Q96A26
Entrez Gene ID: (Human) 26355