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Invitrogen
FAM178A Polyclonal Antibody
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产品信息
PA5-66091
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: ASKYLAKGTNI YVPSSYHLPK EMKSLKKKHR SPERRKSLFI HENNEKNDRD RGKTNADSKK QTTVAEADIF NNSSRSLS
Highest antigen sequence identity to the following orthologs - mouse 71%, rat 71%.
靶标信息
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: family with sequence similarity 178, member A; protein FAM178A; SMC5-SMC6 complex localization factor protein 2; Smc5/6 localization factor 1
基因别名: C10orf6; FAM178A; SLF2
UniProt ID: (Human) Q8IX21
Entrez Gene ID: (Human) 55719
