Abnova

FAM21C Polyclonal Antibody, MaxPab™

Name: FAM21C Polyclonal Antibody, MaxPab\u2122
Brand: Abnova
SKU: H00253725-B01P

查看其他2个FAM21C抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

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FAM21C Antibody (H00253725-B01P) in WB

Western Blot analysis of FAM21C expression in transfected 293T cell line by FAM21C MaxPab polyclonal antibody. Lane 1: FAM21C transfected lysate(31.13 KDa). Lane 2: Non-transfected lysate. .

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产品信息

H00253725-B01P

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG

分类

Polyclonal

类型

Antibody

抗原

FAM21C (AAH06456, 1 a.a. approximately 283 a.a) full-length human protein.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Product may be used with Western Blot (Transfected lysate).

The Isotype of this product is composed of an IgG Mixture.

Immunogen sequence: MSVPRGPIAQ WADGAISPNG HRPQLRAASG EDSTEEALAA AAAPWEGGPV PGVDTSPFAK SLGHSRGEAD LFDSGDIFST GTGSQSVERT KPKAKIAENP ANPPVGGKAK SPMFPALGEA SSDDDLFQSA KPKPAKKTNP FPLLEDEDDL FTDQKVKKNE TKSSSQQDVI LTTQDIFEDD IFATEAIKPS QKTREKEKTL ESNLFDDNID IFADLTVKPK EKSKKKVEAK SIFDDDMDDI FSTGIQAKTT KPKSRSAQAA PEPRFEHKVS NIFDDPLNAF GGQ

靶标信息

Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission (PubMed:19922874, PubMed:20498093, PubMed:22513087, PubMed:23331060). Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35 (PubMed:24980502). Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L (PubMed:25355947, PubMed:28892079). [UniProt]

仅用于科研。不用于诊断过程。未经明确授权不得转售。