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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: DHQHSAQVKR PSVSKEGRKT SIKSHMSGSP GPGGSNTAPS TPVIGGSDKP GMEEKAQPPE AGPQGLHDQG RSSS
Antigen sequence identity: Mouse 77%; Rat 77%
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Chr2Syt; E-Syt2; Extended synaptotagmin-2
基因别名: ESYT2; FAM62B; KIAA1228
Entrez Gene ID: (Human) 57488