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Invitrogen
FAM83B Polyclonal Antibody
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产品信息
PA5-56754
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: ALGDRFEGYD NPENLKANAL YTHSRLRSSL VFKPTLPEQK EVNSCTTGSS NSTIIGSQGS ETPKEVPDTP TNVQHLTDKP LPESIPKLPL QS
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 82%.
靶标信息
The FAM83B gene, also known as Family With Sequence Similarity 83 Member B, is located on chromosome 6q22.1. This gene encodes a protein that functions as an oncogene and plays a crucial role in the development and progression of various human cancers including breast, prostate, and endometrial cancers. FAM83B exerts its oncogenic effects primarily through the PI3K/AKT/mTOR signaling pathway, promoting cell proliferation, migration, and invasion while inhibiting apoptosis. Additionally, FAM83B has been found to regulate mitochondrial metabolism and maintain cellular energy homeostasis. Knockdown studies of FAM83B in cancer cell lines have demonstrated significant reductions in tumor growth and metastatic potential, highlighting its potential as a therapeutic target. The gene includes multiple exons and undergoes alternative splicing, contributing to its functional diversity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: family with sequence similarity 83, member B; Protein FAM83B
基因别名: C6orf143; FAM83B
UniProt ID: (Human) Q5T0W9
Entrez Gene ID: (Human) 222584
