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Invitrogen
FANCM Polyclonal Antibody
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FANCM Antibody (PA5-103839) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded FANCM in rat kidney tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with FANCM polyclonal antibody (Product # PA5-103839) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-103839
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human FANCM(Accession Q8IYD8), corresponding to amino acid residues H447-S497.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total FANCM.
靶标信息
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-dependent RNA helicase FANCM; FAAP250; Fanconi anemia group M protein; Fanconi anemia group M protein homolog; Fanconi anemia, complementation group M; Fanconi anemia-associated polypeptide of 250 kDa; Protein FACM; Protein Hef ortholog
基因别名: AI427100; C730036B14Rik; D12Ertd364e; FAAP250; FANCM; KIAA1596; RGD1307897
UniProt ID: (Human) Q8IYD8, (Mouse) Q8BGE5
Entrez Gene ID: (Human) 57697, (Mouse) 104806, (Rat) 314172
