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Invitrogen
FBXO15 Polyclonal Antibody
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产品信息
PA5-43963
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human FBXO15 (aa 147-196).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Peptide sequence: QDKEAGYWKK EYITKQIASV KAALADILKP VNPYTGLPVK TKEALRIFGL
Sequence homology: Cow: 79%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
靶标信息
F-box protein 15 (FBXO15) is a gene located on chromosome 20p11.1 that encodes a member of the F-box protein family, known for their role in ubiquitin-mediated proteolysis. Proteins in this family contain an F-box domain, enabling them to form part of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which targets specific proteins for ubiquitination and subsequent degradation. FBXO15 is involved in regulating various cellular processes by controlling the turnover of proteins related to cell cycle progression, signal transduction, and development. Its function is crucial for maintaining cellular homeostasis, where dysregulation of FBXO15 can impact protein degradation pathways, potentially leading to disorders such as cancer due to uncontrolled cell proliferation. Current research is focused on understanding the specific targets and functions of FBXO15 within the ubiquitin proteasome system and its potential as a therapeutic target in diseases characterized by aberrant proteolytic activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: F-box only protein 15; MGC39671
基因别名: FBX15; FBXO15
UniProt ID: (Human) Q8NCQ5
Entrez Gene ID: (Human) 201456
