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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Two transcript variants encoding different isoforms exist for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: F-box only protein 22; F-box protein FBX22p44; FIST domain containing 1
基因别名: 0610033L19Rik; 1600016C16Rik; FBX22; FBXO22; FISTC1
UniProt ID: (Human) Q8NEZ5, (Mouse) Q78JE5
Entrez Gene ID: (Human) 26263, (Mouse) 71999