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Abnova
FEM1B Monoclonal Antibody (4B12)
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产品信息
H00010116-M09
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4B12
抗原
FEM1B (NP_056137.1, 401 a.a. approximately 490 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunogen sequence: TVKAPDIECV LRCSVLEIEQ SMNRVKNISD ADVHNAMDNY ECNLYTFLYL VCISTKTQCS EEDQCKINKQ IYNLIHLDPR TREGFTLLHL
靶标信息
Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha and FEM1-b. F1Aalpha/FEM1-b is the homologue of C. elegans sex determining protein FEM-1. FEM-1/F1Aalpha is cleaved by CED-3 and caspase. FEM-1/F1Aalpha associates with CED-4 and its mammalian homologue Apaf-1. Overexpression of F1Aalpha induces apoptosis. F1Aalpha is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aalpha is expressed in a variety of human and mouse tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp451E0710; F1A-alpha; FEM-1-like death receptor binding protein; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; FEM1-beta; FEM1b; FIAA; Protein fem-1 homolog B
基因别名: F1A-ALPHA; F1AA; FEM1-beta; FEM1B; KIAA0396
UniProt ID: (Human) Q9UK73
Entrez Gene ID: (Human) 10116
apoptotic process
protein ubiquitination
regulation of ubiquitin-protein transferase activity
branching involved in prostate gland morphogenesis
epithelial cell maturation involved in prostate gland development
regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of DNA damage checkpoint
