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Abnova
FERMT3 Polyclonal Antibody, MaxPab™
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产品信息
H00083706-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
FERMT3 (NP_113659.3, 1 a.a. approximately 663 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MAGMKTASGD YIDSSWELRV FVGEEDPEAE SVTLRVTGES HIGGVLLKIV EQINRKQDWS DHAIWWEQKR QWLLQTHWTL DKYGILADAR LFFGPQHRPV ILRLPNRRAL RLRASFSQPL FQAVAAICRL LSIRHPEELS LLRAPEKKEK KKKEKEPEEE LYDLSKVVLA GGVAPALFRG MPAHFSDSAQ TEACYHMLSR PQPPPDPLLL QRLPRPSSLS DKTQLHSRWL DSSRCLMQQG IKAGDALWLR FKYYSFFDLD PKTDPVRLTQ LYEQARWDLL LEEIDCTEEE MMVFAALQYH INKLSQSGEV GEPAGTDPGL DDLDVALSNL EVKLEGSAPT DVLDSLTTIP ELKDHLRIFR PRKLTLKGYR QHWVVFKETT LSYYKSQDEA PGDPIQQLNL KGCEVVPDVN VSGQKFCIKL LVPSPEGMSE IYLRCQDEQQ YARWMAGCRL ASKGRTMADS SYTSEVQAIL AFLSLQRTGS GGPGNHPHGP DASAEGLNPY GLVAPRFQRK FKAKQLTPRI LEAHQNVAQL SLAEAQLRFI QAWQSLPDFG ISYVMVRFKG SRKDEILGIA NNRLIRIDLA VGDVVKTWRF SNMRQWNVNW DIRQVAIEFD EHINVAFSCV SASCRIVHEY IGGYIFLSTR ERARGEELDE DLFLQLTGGH EAF
靶标信息
The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Fermitin family homolog 3; kindlin 3; Kindlin-3; MGC10966; MIG2-like protein; UNC-112 related protein 2; Unc-112-related protein 2
基因别名: FERMT3; KIND3; MIG-2; MIG2B; UNC112C; URP2; URP2SF
UniProt ID: (Human) Q86UX7
Entrez Gene ID: (Human) 83706
