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Invitrogen
FES Polyclonal Antibody
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FES Antibody (PA5-96171) in WB
Western blot analysis of FES in extracts of various cell lines. Samples were incubated with FES Polyclonal antibody (Product # PA5-96171) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
产品信息
PA5-96171
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 120-420 of human FES (NP_0011372561)
偶联物
形式
Liquid
浓度
0.19 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: WQQLQQELTK THSQDIEKLK SQYRALARDS AQAKRKYQEA SKDKDRDKAK DKYVRSLWKL FAHHNRYVLG VRAAQLHHQH HHQLLLPGLL RSLQDLHEEM ACILKEILQE YLEISSLVQD EVVAIHREMA AAAARIQPEA EYQGFLRQYG SAPDVPPCVT FDESLLEEGE PLEPGELQLN ELTVESVQHT LTSVTDELAV ATEMVFRRQE MVTQLQQELR NEEENTHPRE RVQLLGKRQV LQEALQGLQV ALCSQAKLQA QQELLQTKLE HLGPGEPPPV LLLQDDRHST SSSEQEREGG R; Positive Samples: Mouse heart, Mouse brain; Cellular Location: Cell junction, Cell membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus, Peripheral membrane protein, cytoskeleton, cytosol, focal adhesion
靶标信息
FES (FPS) is a tyrosine protein kinase that is required for maintenance of cellular transformation. Its chromosomal location is linked to a specific translocation event identified in patients with acute promyelocytic leukemia, and it is also involved in normal hematopoiesis. Alternative splicing results in multiple variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EC 2.7.10.2; Proto-oncogene c-Fes; proto-oncogene tyrosine-protein kinase Fes/Fps; tyrosine kinase Fps/Fes; Tyrosine-protein kinase Fes/Fps; Variant 4
基因别名: AI586313; BB137047; c-fes; Fes; FPS
UniProt ID: (Mouse) P16879
Entrez Gene ID: (Mouse) 14159
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
microtubule binding
lipid binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
immunoglobulin receptor binding
phosphatidylinositol binding
microtubule bundle formation
protein phosphorylation
chemotaxis
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of cell shape
positive regulation of neuron projection development
phosphorylation
cell migration
peptidyl-tyrosine phosphorylation
cell differentiation
regulation of cell adhesion
positive regulation of microtubule polymerization
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
regulation of mast cell degranulation
innate immune response
regulation of cell differentiation
positive regulation of myeloid cell differentiation
protein autophosphorylation
centrosome organization
regulation of cell motility
positive regulation of actin cytoskeleton reorganization
