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Immunogen sequence: YLGLLSENCL HSPRLAAAVR EFEQSVQGGS QTAKHRLLRV VQRLFQYQVL LTDYLNNLCP DSAEYDNTQG ALSLISKVTD RANDSMEQGE NLQKLVHIEH SVRGQGDLLQ PGREFLKEGT LMKVTGKNRR PRHLFLMNDV LLYTYPQKDG KYRLKNTLAV ANMKVSRPVM EKVPYALKIE TSESCLMLSA SSCAERDEWY G; Positive Samples: Mouse brain; Cellular Location: Cell projection, Cytoplasm, Early endosome, Endoplasmic reticulum, Golgi apparatus, cytoskeleton, ruffle membrane
FGD5 activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. It mediates VEGF-induced CDC42 activation. It may regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation and may play a role in regulating the actin cytoskeleton and cell shape.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FYVE, RhoGEF and PH domain-containing protein 5
基因别名: C330025N11Rik; Fgd5; mFLJ00274; ZFYVE23
UniProt ID: (Mouse) Q80UZ0
Entrez Gene ID: (Mouse) 232237
分子生物学功能: G-protein modulator protein-binding activity modulator guanyl-nucleotide exchange factor