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Invitrogen
FGFR1 Monoclonal Antibody (M2F12)
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FGFR1 Antibody (MA1-26256) in WB
Cellular and molecular life sciences : CMLS 2022 -
Glucocorticoid suppresses neurogenesis by reducing astrocytic HMW FGF2 and its downstream INFS. a After exposure to prenatal vehicle or corticosterone (10 mg/kg) at E14, the hippocampus from mice at P1 was collected. RNA sequencing was performed using RNA extracted from the hippocampal tissue. The scatter plot represents the log-fold changes between the mice exposed to prenatal vehicle (control) and the mic... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA1-26256
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
M2F12
抗原
Recombinant human ectodomain of FGFr1alpha expressed in E. coli beginning with pro23. Antigen contained NH2-terminal gly-ser-pro-gly-ile and COOH- terminal glu-phe sequences.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
125 µg
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). The FGF Receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. FGFR1 is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. Other defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, Antley-Bixler syndrome. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 2.7.10.1; Basic fibroblast growth factor receptor 1; bFGF-R; bFGF-R-1; BFGFR; c-fgr; CD331; CD331 antigen; FGF Receptor; FGF receptor-1; FGFR; fgfr 1; FGFR-1; Fibroblast growth factor receptor 1; FLT-2; Fms-like tyrosine kinase 2; MFR; N-sam; Proto-oncogene c-Fgr
基因别名: AW208770; bFGF-R-1; BFGFR; c-fgr; CEK; Eask; FGFBR; Fgfr-1; FGFR1; FLG; Flt-2; FLT2; HBGFR; Hspy; MFR
UniProt ID: (Rat) Q04589, (Mouse) P16092
Entrez Gene ID: (Rat) 79114, (Mouse) 14182
glycoprotein binding
protein tyrosine kinase activity
fibroblast growth factor-activated receptor activity
protein binding
ATP binding
heparin binding
fibroblast growth factor binding
protein complex binding
identical protein binding
protein homodimerization activity
cell adhesion molecule binding
nucleotide binding
protein kinase activity
transmembrane receptor protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
ureteric bud development
in utero embryonic development
organ induction
positive regulation of mesenchymal cell proliferation
chondrocyte differentiation
brain development
salivary gland morphogenesis
sensory perception of sound
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
regulation of gene expression
negative regulation of gene expression
positive regulation of phospholipase C activity
positive regulation of neuron projection development
peptidyl-tyrosine phosphorylation
stem cell population maintenance
orbitofrontal cortex development
motogenic signaling involved in postnatal olfactory bulb interneuron migration
ventricular zone neuroblast division
central nervous system neuron development
lung development
embryonic limb morphogenesis
midbrain development
neuron projection development
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
regulation of cell proliferation
inner ear morphogenesis
outer ear morphogenesis
middle ear morphogenesis
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of neuron differentiation
negative regulation of osteoblast differentiation
positive regulation of cell cycle
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
paraxial mesoderm development
regulation of lateral mesodermal cell fate specification
cell maturation
blood vessel morphogenesis
generation of neurons
mesenchymal cell differentiation
regulation of sensory perception of pain
positive regulation of cardiac muscle cell proliferation
auditory receptor cell development
branching involved in salivary gland morphogenesis
lung-associated mesenchyme development
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
regulation of stem cell proliferation
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
regulation of extrinsic apoptotic signaling pathway in absence of ligand
protein phosphorylation
phosphorylation
vasculogenesis involved in coronary vascular morphogenesis
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