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Invitrogen
FGFR1OP2 Polyclonal Antibody
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FGFR1OP2 Antibody (PA5-97749) in WB
Western Blot analysis of FGFR1OP2 using a FGFR1OP2 Polyclonal antibody (Product # PA5-97749) at a concentration of 6 µg/mL. Lane 1: Mouse gonadal tissue. Lane 2: Human placenta tissue. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:10,000 dilution. Observed band size: 30 kDa.
产品信息
PA5-97749
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human FGFR1 oncogene partner 2 protein (1-172AA)
偶联物
形式
Liquid
浓度
3 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
FGFR1OP2, also known as FGFR1 oncogene partner 2, is a gene that plays a crucial role in oncogenesis, particularly in myeloproliferative neoplasms. It is known to interact with the FGFR1 (Fibroblast Growth Factor Receptor 1) through chromosomal translocations that can lead to malignancies, such as the formation of the fusion protein FGFR1OP2-FGFR1 in KG-1a leukemic cells. FGFR1OP2 itself is a gene encoding a protein whose function is not entirely understood, but its association with FGFR1 highlights its potential role in oncogenic pathways. The FGFR1 component of the fusion is a receptor tyrosine kinase involved in various cellular processes like cell proliferation, migration, and differentiation. The disruption of these processes through abnormal expression or structural changes such as fusions can lead to uncontrolled cell growth and malignancies. FGFR1 is also frequently studied as a therapeutic target in cancer, given its importance in cellular signaling and cancer progression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FGFR1 oncogene partner 2; FGFR1 oncogene partner 2 homolog; fibroblast growth factor receptor 1 oncogene partner 2; wound inducible transcript 3.0
基因别名: 1500031J01Rik; FGFR1OP2; HSPC123; HSPC123-like; WIT3.0
UniProt ID: (Human) Q9NVK5, (Mouse) Q9CRA9
Entrez Gene ID: (Human) 26127, (Mouse) 67529
