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Invitrogen
FGFR4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79263
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human FGFR4 recombinant protein (Position: L22-H206).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human PANC whole cell, human SGC whole cell, human COLO320 whole cell, human SW620 whole cell. IHC: human lung cancer tissue.
靶标信息
FGFR4 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR4 is required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. FGFR4 plays a role in postnatal lung development and may be involved in the development of skeletal muscle cell lineages.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD334; FGF Receptor; FGF Receptor 4; FGFR; FGFR-4; FGFR4; FGFR4 variant; ptd-FGFR4; Fibroblast growth factor receptor 4; hydroxyaryl-protein kinase; MGC20292; protein-tyrosine kinase; receptor tyrosine kinase; tyrosine kinase related to fibroblast growth factor receptor; tyrosylprotein kinase; unnamed protein product
基因别名: CD334; FGFR4; JTK2; TKF
UniProt ID: (Human) P22455
Entrez Gene ID: (Human) 2264
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
regulation of gene expression
positive regulation of gene expression
regulation of extracellular matrix disassembly
cell migration
peptidyl-tyrosine phosphorylation
regulation of lipid metabolic process
glucose homeostasis
cholesterol homeostasis
positive regulation of catalytic activity
positive regulation of MAPK cascade
positive regulation of proteolysis
protein autophosphorylation
phosphate ion homeostasis
positive regulation of ERK1 and ERK2 cascade
regulation of bile acid biosynthetic process
response to bile acid
positive regulation of DNA biosynthetic process
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