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Invitrogen
FGFR5 Polyclonal Antibody
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产品信息
PA5-106797
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human FGFRL1(Accession Q8N441), corresponding to amino acid residues N321-S371.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total FGRL1.
靶标信息
Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuro-ectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. A total of six members of the FGF receptor family have been identified and cloned. These include the Flg receptor or FGFR-1, the BEK receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. However, FGFR-5 lacks the cytoplasmic kinase domain. FGFR-5 is expressed in a broad range of tissues, including kidney, brain and lung, but it is preferentially expressed in pancreas, where it may play a role in the regulation of some pancreatic function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FGF homologous factor receptor; FGF receptor-like protein 1; FGFR-5; FGFR-like protein; Fibroblast growth factor receptor 5; Fibroblast growth factor receptor-like 1
基因别名: FGFR5; FGFR5beta; FGFR5gamma; FGFRL1; FHFR; UNQ480/PRO943
UniProt ID: (Human) Q8N441, (Mouse) Q91V87
Entrez Gene ID: (Human) 53834, (Mouse) 116701
skeletal system development
heart valve morphogenesis
negative regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
substrate adhesion-dependent cell spreading
protein homooligomerization
protein heterooligomerization
ventricular septum morphogenesis
diaphragm development
cell-cell adhesion via plasma-membrane adhesion molecules
cell surface receptor signaling pathway
peptidyl-tyrosine phosphorylation
negative regulation of fibroblast growth factor receptor signaling pathway
