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Invitrogen
FGR Monoclonal Antibody (6G2)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-15490
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
6G2
抗原
Purified recombinant fragment of human FGR expressed in E. Coli.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-15490 targets FGR in indirect ELISA, IHC and WB applications and shows reactivity with Human and mouse samples.
The MA5-15490 immunogen is purified recombinant fragment of human FGR expressed in E. Coli.
MA5-15490 detects FGR which has a predicted molecular weight of approximately 56kDa.
靶标信息
FGR is a SRC-related kinase present in hematopoietic cells. FGR signals within multiple pathways including within the integrin pathway and downstream of chemokine and cytokine receptors. This protein contains N-terminal sites for myristylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. It localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EC 2.7.10.2; FGR protein; FLJ43153; MGC75096; OTTHUMP00000003603; OTTHUMP00000003604; p55-Fgr; Proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase Fgr; Tyrosine-protein kinase Fgr
基因别名: Fgr
UniProt ID: (Mouse) P14234
Entrez Gene ID: (Mouse) 14191
nucleotide binding
phosphotyrosine binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
immunoglobulin receptor binding
Fc-gamma receptor I complex binding
immune system process
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
integrin-mediated signaling pathway
regulation of cell shape
positive regulation of phosphatidylinositol 3-kinase signaling
phosphorylation
peptidyl-tyrosine phosphorylation
cell differentiation
positive regulation of cell migration
regulation of actin cytoskeleton organization
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
positive regulation of mast cell degranulation
positive regulation of phosphatidylinositol 3-kinase activity
innate immune response
regulation of innate immune response
regulation of protein kinase activity
protein autophosphorylation
positive regulation of cytokine secretion
regulation of phagocytosis
defense response to Gram-positive bacterium
cellular response to peptide hormone stimulus
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