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Invitrogen
FKBP15 Polyclonal Antibody
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FKBP15 Antibody (PA5-144010) in ICC/IF
Immunocytochemistry analysis of FKBP15 in MCF-7 cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum. Samples were then incubated in FKBP15 Polyclonal antibody (Product # PA5-144010) using a dilution of 5 μg/mL. DyLight®488 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained with DAPI. Visualize using a fluorescence microscope and filter sets appropriat... View More
产品信息
PA5-144010
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human FKBP135/FKBP15 recombinant protein (Position: A19-D1210).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human Hacat whole cell, human Raji whole cell, mouse lung tissue. IHC: human spleen tissue, human tonsil tissue, mouse brain tissue, rat brain tissue, human breast tissue, human lymphoma tissue. ICC/IF: MCF-7 cell. Flow: JK cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins, targets for the immunosupressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif. FKBP15 is distributed along the axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons; overexpression of FKBP15 resulted in the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 has also been shown to associate with both microtubules and the actin filament systems and disruption of its expression by RNAi resulted in delayed transport of early endosomes in HeLa cells indicating that FKBP15 is also involved in the transport of early endosomes. At least three isoforms of FKBP15 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 133 kDa FK506-binding protein; 133 kDa FKBP; FK506 binding protein 15; FK506 binding protein 15, 133kDa; FK506-binding protein 133; FK506-binding protein 133kDa; FK506-binding protein 15; FKBP-133; FKBP-15; protein phosphatase 1, regulatory subunit 76; WAFL; WASP and FKBP-like; WASP and FKBP-like protein; WASP- and FKBP-like protein
基因别名: BB131447; C430014M02Rik; FKBO133; FKBP-133; FKBP-15; FKBP133; FKBP15; KIAA0674; mKIAA0674; PPP1R76; RGD1304816
UniProt ID: (Human) Q5T1M5, (Mouse) Q6P9Q6
Entrez Gene ID: (Human) 23307, (Mouse) 338355, (Rat) 362528
