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Abnova
FKBP1A Monoclonal Antibody (S2)
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产品信息
H00002280-M01J
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
S2
抗原
FKBP1A (AAH05147, 1 a.a. approximately 108 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF DVELLKLE
Cell culture grade monoclonal antibodies are obtained by purifying "hybridoma culture medium" which completely eliminates any contamination of mice. They have high affinity, high purity, and no contamination.
靶标信息
FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 12 kDa FK506-binding protein; 12 kDa FKBP; calstabin 1; Calstabin-1; EC 5.2.1.8; FK506 binding protein 1A, 12kDa; FK506 binding protein12; FK506-binding protein 1; FK506-binding protein 12; FK506-binding protein 1A; FK506-binding protein 1A (12kD); FK506-binding protein, T-cell, 12-kD; FKBP-1A; FKBP12-Exip3; Immunophilin FKBP12; Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; protein kinase C inhibitor 2; Rotamase
基因别名: FKBP-12; FKBP-1A; FKBP1; FKBP12; FKBP1A; PKC12; PKCI2; PPIASE
UniProt ID: (Human) P62942
Entrez Gene ID: (Human) 2280
peptidyl-prolyl cis-trans isomerase activity
signal transducer activity
transforming growth factor beta receptor binding
protein binding
macrolide binding
FK506 binding
calcium channel inhibitor activity
type I transforming growth factor beta receptor binding
ion channel binding
SMAD binding
activin binding
chaperone
protein peptidyl-prolyl isomerization
heart morphogenesis
protein folding
'de novo' protein folding
transforming growth factor beta receptor signaling pathway
SMAD protein complex assembly
protein maturation by protein folding
positive regulation of protein ubiquitination
positive regulation of protein binding
negative regulation of protein phosphatase type 2B activity
regulation of protein localization
regulation of activin receptor signaling pathway
protein refolding
T cell activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
extracellular fibril organization
regulation of immune response
negative regulation of release of sequestered calcium ion into cytosol
ventricular cardiac muscle tissue morphogenesis
regulation of ryanodine-sensitive calcium-release channel activity
negative regulation of ryanodine-sensitive calcium-release channel activity
heart trabecula formation
chaperone-mediated protein folding
calcium ion transmembrane transport
regulation of amyloid precursor protein catabolic process
amyloid fibril formation
