Invitrogen

FKBP4 Polyclonal Antibody

Name: FKBP4 Polyclonal Antibody
Brand: Invitrogen
SKU: PA3-020

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4 篇参考文献

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说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)
已发表图片 (1)

FKBP4 Antibody in Immunocytochemistry (ICC/IF)

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FKBP4 Antibody (PA3-020) in ICC/IF

Immunofluorescent analysis of Heat Shock protein 56 (HSP56, green) in HeLa cells. Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 1% Blocker BSA (Product # 37525) for 15 minutes at room temperature. Cells were probed without (left panel) or with (right panel) a HSP56 polyclonal antibody (Product # PA3-020) at a dilution of 1:100 for at least 1 hour at room temperature, washed with PBS, and incubated with DyLight 488 goat anti-rabbit IgG secondary antibody (Product # ... View More

FKBP4 Antibody in Immunohistochemistry (Frozen) (IHC (F))

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Immunogen image

Immunogen Image FKBP4 Polyclonal Antibody

产品信息

PA3-020

应用

建议稀释比

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免疫印迹 (WB)

1:1,000

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免疫组化 (IHC)

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免疫组化（冰冻） (IHC (F))

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免疫细胞化学 (ICC/IF)

1:100

产品规格

种属反应

Human, Mouse, Non-human primate, Rabbit

已发表种属

Mouse, Non-human primate, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues C(441) K D E R N D V A G S Q S Q V E T E A(458) of rabbit Heat Shock Protein 56.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_325971

产品详细信息

PA3-020 detects heat shock protein 56 (HSP56), also known as FKBP4/FKBP52, from human, monkey, mouse and rabbit tissues.

PA3-020 has been successfully used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects a prominent ~52 kDa band representing HSP56 HeLa cell lysate.

The PA3-020 immunogen is a synthetic peptide corresponding to residues C(441) K D E R N D V A G S Q S Q V E T E A(458) of rabbit Heat Shock Protein 56.

Reconstitute in 100 µL PBS to create a stock of 1 mg/mL.

靶标信息

FKBP4, encoding FK506-binding protein 4, is part of the immunophilin family and plays roles in cellular processes like protein folding and trafficking. The FKBP4 gene is located on chromosome 12, where it encodes a protein involved in modulating the androgen receptor signaling pathway and has been implicated in various cancers, including non-small-cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC). Structural variants of FKBP4 found through exome sequencing have shown potential deleterious effects on protein function. This gene is associated with cell proliferation, apoptosis, migration, and invasion in cancer cells. FKBP4 also influences metabolic processes, such as glycolysis, thereby contributing to cancer cell survival and growth. Importantly, FKBP4 has a role in disorders of sexual development due to its regulatory interaction with hormone signaling pathways.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: 51 kDa FK506-binding protein; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 4, 59kDa; FK506-binding protein 4; FK506-binding protein 4 (59kD); FKBP-4; FKBP51; FKBP59; HBI; HSP binding immunophilin; HSP-binding immunophilin; hsp90 binding protein; Immunophilin FKBP52; p59; Peptidyl-prolyl cis-trans isomerase FKBP4; peptidylprolyl cis-trans isomerase; PPIase FKBP4; Rotamase; T-cell FK506-binding protein, 59kD

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基因别名: 59kDa; AL022792; AW208983; FKBP-4; FKBP-52; FKBP4; FKBP51; FKBP52; FKBP59; FKPB52; HBI; Hsp56; p52; P59; PPIase

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UniProt ID: (Rabbit) P27124, (Human) Q02790, (Mouse) P30416

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Entrez Gene ID: (Rabbit) 100009148, (Human) 2288, (Mouse) 14228

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功能