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Invitrogen
FLAP Polyclonal Antibody
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产品信息
PA5-103074
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ALOX5AP(Accession P20292), corresponding to amino acid residues A83-Y133.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total ALOX5AP.
靶标信息
ALOX5AP is a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5-lipoxygenase-activating protein FLAP; Arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein
基因别名: ALOX5AP; FLAP
UniProt ID: (Human) P20292, (Rat) P20291
Entrez Gene ID: (Human) 241, (Rat) 29624
glutathione transferase activity
leukotriene-C4 synthase activity
glutathione peroxidase activity
protein binding
enzyme activator activity
protein N-terminus binding
arachidonic acid binding
arachidonate 5-lipoxygenase activity
enzyme binding
protein homodimerization activity
protein heterodimerization activity
transferase
leukotriene metabolic process
leukotriene biosynthetic process
lipoxygenase pathway
positive regulation of catalytic activity
protein homotrimerization
cellular response to calcium ion
lipoxin metabolic process
leukotriene production involved in inflammatory response
positive regulation of acute inflammatory response
oxidation-reduction process
