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PA1-4168 detects the FLASH protein in mouse samples.
PA1-4168 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~212 kDa protein representing FLASH in NIH3T3 cells.
The PA1-4168 immunogen is a synthetic peptide corresponding to residues W(1909) T R N D D R E I L L E(1920) of mouse FLASH.
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CASP8-associated protein 2; casp8ap2; FLICE-associated huge protein; FLJ11208; RP11-63K6.3
基因别名: AA387232; Casp8ap2; D4Ertd659e; FLASH; mKIAA1315
UniProt ID: (Mouse) Q9WUF3
Entrez Gene ID: (Mouse) 26885