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Invitrogen
FLIP Polyclonal Antibody
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FLIP Antibody (PA5-26132) in IHC (P)
Immunohistochemistry analysis of FLIP in formalin-fixed and paraffin-embedded human skeletal muscle. Samples were incubated with FLIP polyclonal antibody (Product # PA5-26132) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-26132
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 145-174 amino acids from the central region of human CFLAR
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
2 mg/mL
规格
800 µg
纯化类型
Size-exclusion - Dialysis, Ammonium sulfate precipitation
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
FLIP (CFLAR) is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: caspase homolog; caspase-eight-related protein; caspase-like apoptosis regulatory protein; caspase-related inducer of apoptosis; cellular FLICE-like inhibitory protein; DED-caspase homologue; FADD-like antiapoptotic molecule 1; FLIP-L; apoptosis inhibitor; FLIP-S; apoptosis inhibitor; inhibitor of FLICE; MACH-related inducer of toxicity; testis secretory sperm-binding protein Li 233m; unnamed protein product; usurpin beta
基因别名: c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT
UniProt ID: (Human) O15519
Entrez Gene ID: (Human) 8837
response to hypoxia
proteolysis
apoptotic process
skeletal muscle tissue development
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of cardiac muscle cell apoptotic process
positive regulation of neuron projection development
skeletal muscle atrophy
regulation of skeletal muscle satellite cell proliferation
skeletal myofibril assembly
macrophage differentiation
cellular response to insulin stimulus
response to testosterone
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
skeletal muscle tissue regeneration
positive regulation of neuron apoptotic process
regulation of necroptotic process
positive regulation of ERK1 and ERK2 cascade
cellular response to epidermal growth factor stimulus
cellular response to estradiol stimulus
cellular response to hypoxia
cellular response to dexamethasone stimulus
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of glomerular mesangial cell proliferation
negative regulation of myoblast fusion
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of extracellular matrix organization
negative regulation of reactive oxygen species biosynthetic process
negative regulation of cellular response to transforming growth factor beta stimulus
negative regulation of hepatocyte apoptotic process
negative regulation of epithelial cell apoptotic process
positive regulation of hepatocyte proliferation
negative regulation of extrinsic apoptotic signaling pathway
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