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Agrisera
FLS2/Flagellin-sensitive 2 Polyclonal Antibody
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FLS2/Flagellin-sensitive 2 Antibody (AS12-1857) in WB
Plant material: Arabidopsis thaliana Col-0 (wild type) fls 2 c mutant (described in Nekrasov et al. 2009). Method: Two-week-old seedlings (grown under short day conditions, 8 h light) were collected and frozen in liquid nitrogen. Approximately 100 mg of plant material were extracted in 0.2 mL of homogenization buffer (250 m M sucrose, 50 m M HEPES-KOH p H 7.5,5% glycerol, 0.5% Triton X-100,50 m M Na 4 P 2 O... View More
产品信息
AS12-1857
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated peptide derived from Arabidopsis thaliana FLS2 sequence.
偶联物
形式
Lyophilized
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles,Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
靶标信息
FLS2 encodes a plasma membrane-localized leucine-rich repeat receptor kinase that functions at the cell surface to detect bacterial flagellin-derived epitopes (notably the conserved peptide flg22) and initiate pattern-triggered immunity. The protein is a single-pass transmembrane receptor with a large extracellular ectodomain composed of multiple leucine-rich repeats (commonly described as 28 LRRs) that mediate ligand perception, flanked by conserved cysteine motifs important for proper maturation and receptor competence, and a cytosolic serine/threonine kinase domain required for downstream signaling. Upon flg22 perception, FLS2 rapidly forms an activated receptor complex with the co-receptor kinase BAK1, enabling transphosphorylation-dependent signal propagation that drives early immune outputs such as oxidative burst, defense gene induction, and broad antibacterial resistance. Loss-of-function alleles disrupt flagellin binding and/or signaling, demonstrating that both the extracellular LRR region and intracellular kinase activity are essential for full receptor function in vivo.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AT5G46330; FLAGELLIN-SENSING 2; FLAGELLIN-SENSITIVE 2; MPL12.13; MPL12.8; MPL12_13
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