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Invitrogen
FLT3 (CD135) Polyclonal Antibody
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产品信息
PA5-79270
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived mouse Flt3 / CD135 recombinant protein (Position: E62-E295).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: mouse brain tissue. IHC: mouse small intestine tissue, rat kidney tissue, rat liver tissue, rat small intestine tissue, mouse kidney tissue.
靶标信息
FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD135; Fetal liver kinase 2; FL cytokine receptor; FLK-2; FLT-3; Fms-like tyrosine kinase 3; OTTHUMP00000214829; Receptor-type tyrosine-protein kinase FLT3; RP11-153M24.3; tyrosine-protein kinase FLT3; Tyrosine-protein kinase receptor flk-2
基因别名: B230315G04; CD135; Flk-2; Flk2; Flt-3; Flt3; Ly72; wmfl
UniProt ID: (Mouse) Q00342
Entrez Gene ID: (Rat) 140635, (Mouse) 14255
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
cytokine receptor activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
ubiquitin protein ligase binding
protein complex binding
glucocorticoid receptor binding
phosphatidylinositol 3-kinase binding
transmembrane signal receptor
leukocyte homeostasis
positive regulation of protein phosphorylation
myeloid progenitor cell differentiation
lymphoid progenitor cell differentiation
pro-B cell differentiation
pro-T cell differentiation
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of cell proliferation
phosphorylation
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
hemopoiesis
lymphocyte differentiation
cell differentiation
B cell differentiation
common myeloid progenitor cell proliferation
negative regulation of B cell differentiation
lymphocyte proliferation
protein autophosphorylation
cellular response to cytokine stimulus
dendritic cell differentiation
