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Invitrogen
FMRP Monoclonal Antibody (6A15)
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产品信息
MA1-5771
应用
建议稀释比
已发表文章
产品规格
种属反应
Fruit fly
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
6A15
抗原
His-dFMR1 fusion protein (Drosophila melanogaster) (C-terminal 580aa) (aa 580-684).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-5771 detects FMR1 in drosophila samples (does not cross react with human). Western blot detects a band of approximately 85kDa (predicted molecular weight: 82kDa).
靶标信息
FMR1 binds RNA and is associated with polysomes. The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure. Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cg 6203 gene product from transcript cg6203-rc; CG6203-PA; CG6203-PB; CG6203-PC; CG6203-PD; CG6203-PE; CG6203-PF; CG6203-PG; CG6203-PH; CG6203-PI; CG6203-PJ; CG6203-PK; dFMR; dFmr1; drosophila fragile X mental retardation protein; Fmr1-PA; Fmr1-PB; Fmr1-PC; Fmr1-PD; Fmr1-PE; Fmr1-PF; Fmr1-PG; Fmr1-PH; Fmr1-PI; Fmr1-PJ; Fmr1-PK; FMRP; fragile X; fragile X mental retardation; fragile X mental retardation 1; fragile X mental retardation gene; fragile X mental retardation protein; fragile X mental retardation protein 1; fragile X mental retardation related 1; Fragile X messenger ribonucleoprotein 1 homolog; fragile X protein; fragile x related; fragile X related protein; fragile X retardation 1 protein; fragile X-related; fragile-X; Fragile-X mental retardation 1; Fragile-X mental retardation protein; Fragile-X-related; FXR; MGC87458
基因别名: AT24755; BcDNA:GM08679; CG6203; dFMR; DFmr1; DFMRP; dFXR; dFXR1; dFXRP; Dmel\CG6203; Dmel_CG6203; dmfr1; EP(3)3517; FMR; FMR1; FMRP; FXR
UniProt ID: (Fruit fly) Q9NFU0
Entrez Gene ID: (Fruit fly) 37528
positive regulation of neuroblast proliferation
regulation of translation
chemotaxis
chemical synaptic transmission
pole cell formation
germ cell development
sperm axoneme assembly
germarium-derived oocyte fate determination
oocyte dorsal/ventral axis specification
cellularization
axonogenesis
axon guidance
axonal fasciculation
central nervous system development
brain development
neuromuscular junction development
short-term memory
long-term memory
circadian rhythm
grooming behavior
male courtship behavior
anterograde axonal transport
associative learning
adult locomotory behavior
larval locomotory behavior
olfactory learning
regulation of mitotic cell cycle, embryonic
posttranscriptional regulation of gene expression
negative regulation of gene expression
mushroom body development
neuron remodeling
negative regulation of translation
gene silencing by RNA
heterochromatin assembly
social behavior
locomotion
olfactory behavior
regulation of cell proliferation
phototaxis
positive regulation of programmed cell death
regulation of mRNA stability
mitotic cell cycle, embryonic
locomotor rhythm
negative regulation of imaginal disc growth
positive regulation of translation
negative regulation of synaptic growth at neuromuscular junction
negative regulation of insulin receptor signaling pathway
habituation
germ-line cyst formation
post-embryonic digestive tract morphogenesis
neuron projection morphogenesis
dendrite morphogenesis
regulation of dendrite morphogenesis
negative regulation of dendrite morphogenesis
circadian sleep/wake cycle, sleep
regulation of synapse organization
synapse organization
detection of mechanical stimulus involved in sensory perception of touch
mRNA transport
regulation of synapse structural plasticity
negative regulation of synapse assembly
regulation of dendritic spine development
synaptic vesicle budding
medium-term memory
terminal button organization
regulation of olfactory learning
synaptic vesicle clustering
synapse pruning
regulation of translation at postsynapse, modulating synaptic transmission
regulation of neuromuscular synaptic transmission
negative regulation of mRNA polyadenylation
regulation of modification of synaptic structure
response to odorant
negative regulation of stem cell proliferation
