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Invitrogen
FNIP1 Polyclonal Antibody
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产品信息
PA5-64359
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: HHTKPLKEER GAIDQHQETK QTTKDQSGES DTQNMVSEEP CELPCWNHSD PESMSLFDEY FNDDSIETRT IDDVPF
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 79%.
靶标信息
FNIP1 encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. Diseases associated with FNIP1 include Birt-Hogg-Dube Syndrome and Pleural Disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Folliculin-interacting protein 1
基因别名: FNIP1; KIAA1961
UniProt ID: (Human) Q8TF40
Entrez Gene ID: (Human) 96459
negative regulation of transcription from RNA polymerase II promoter
regulation of protein phosphorylation
positive regulation of protein phosphorylation
immature B cell differentiation
positive regulation of B cell apoptotic process
cellular response to starvation
positive regulation of protein complex assembly
TOR signaling
negative regulation of TOR signaling
positive regulation of peptidyl-serine phosphorylation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of GTPase activity
regulation of pro-B cell differentiation
