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Invitrogen
FNTA Recombinant Rabbit Monoclonal Antibody (25GB4325)
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FNTA Antibody (MA570999) in ICC/IF
Immunocytochemistry analysis of FNTA in HepG2 cells. Sample was incubated with FNTA monoclonal antibody (Product # MA570999) at a dilution of 1:1,000. Nuclei were stained blue with DAPI and Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
产品信息
MA570999
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
25GB4325
抗原
A synthesized peptide derived from human FNTA. The antigenic range is proprietary.
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Dry ice (international)
靶标信息
FNTA (Farnesyltransferase, CAAX box; alphaCAAX farnesyltransferase alpha subunit, FPTA, FTase-alpha, GGTase-I-alpha, Protein farnesyl transferase/ geranyl geranyl transferase type I alpha subunit(PGGT1A), Ras proteins prenyl transferase alpha, Type I protein geranyl-geranyl transferase alpha subunit) is located locus 8p11 (human). Prenylation is a common intracellular posttranslational protein modification catalyzed by prenyltransferases. The best characterized among these prenyltransferases is the CAAX farnesyl transferase (2. 5. 1. 21), which is alpha-beta heterodimeric enzyme. It catalyzes the attachment of a farnesyl group from farnesyl phosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box. FNTA or the alpha subunit of farnesyl transferase is shared by the geranyl-geranyl protein transferases. Apart from transfer of farnesyl and geranyl groups to proteins, FNTA has been proposed to regulate intracellular signaling pathways involving p21ras. Reports have shown that FNTA interacts with TGF-beta and activin-type I receptors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CAAX farnesyltransferase subunit alpha; farnesyl-protein transferase alpha-subunit; Farnesyltransferase, subunit alpha; FTase-alpha; GGTase-I-alpha; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; protein prenyltransferase alpha subunit repeat containing 2; Ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase alpha subunit; Type I protein geranyl-geranyltransferase subunit alpha
基因别名: FNTA; FPTA; FTA; PFAS; PGGT1A; PTAR2
UniProt ID: (Human) P49354, (Rat) Q04631, (Mouse) Q61239
Entrez Gene ID: (Human) 2339, (Rat) 25318, (Mouse) 14272
protein farnesyltransferase activity
protein geranylgeranyltransferase activity
CAAX-protein geranylgeranyltransferase activity
Rab geranylgeranyltransferase activity
protein binding
microtubule binding
acetylcholine receptor regulator activity
receptor tyrosine kinase binding
alpha-tubulin binding
drug binding
zinc ion binding
isoprenoid binding
peptide binding
prenyltransferase activity
protein prenyltransferase activity
transferase activity
acyltransferase
viral or transposable element protein
cellular component disassembly involved in execution phase of apoptosis
transforming growth factor beta receptor signaling pathway
protein farnesylation
protein geranylgeranylation
regulation of rhodopsin mediated signaling pathway
neurotransmitter receptor metabolic process
skeletal muscle acetylcholine-gated channel clustering
positive regulation of tubulin deacetylation
positive regulation of deacetylase activity
regulation of neurotransmitter receptor activity
positive regulation of cell proliferation
response to inorganic substance
regulation of receptor activity
response to organic cyclic compound
response to cytokine
negative regulation of apoptotic process
positive regulation of cell cycle
positive regulation of nitric-oxide synthase biosynthetic process
negative regulation of nitric-oxide synthase biosynthetic process
protein prenylation
