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FOLH1/PSMA Antibody (2346-MSM3-P1) in IHC (P)
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded canine kidney stained with FOLH1/PSMA Monoclonal Antibody (Product # 2346-MSM3-P1) at a dilution of 2 µg/mL in PBS for 30 minutes at room temperature. HIER: Tris/EDTA, pH9.0, 45 min. 2 °C: HRP-polymer, 30 min. DAB, 5 min.
产品信息
2346-MSM3-P1
产品规格
种属反应
Bovine,
Dog,
Human,
Rat
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
FOLH1, 2363
抗原
Recombinant human FOLH1 protein fragment (around aa 232-433)
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
靶标信息
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cell growth-inhibiting gene 27 protein; FGCP; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; GCPII; glutamate carboxylase II; Glutamate carboxypeptidase 2; Glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; mGCP; N-acetylated alpha-linked acidic dipeptidase; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; prostate specific membrane antigen; prostate specific membrane antigen variant F; Prostate-specific membrane antigen; Prostate-specific membrane antigen homolog; PSM; Pteroylpoly-gamma-glutamate carboxypeptidase
基因别名: FGCP; FOLH; FOLH1; GCP2; GCPII; GIG27; mGCP; Naalad; NAALAD1; NAALAdase; PSM; PSMA
UniProt ID: (Human) Q04609, (Rat) P70627
Entrez Gene ID: (Human) 2346, (Dog) 476775, (Rat) 85309
