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Invitrogen
FOXA2 Polyclonal Antibody
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FIGURE: 1 / 4
FOXA2 Antibody (720061) in ICC/IF
Immunofluorescence was performed on fixed and permeabilized MCF-7 cells for detection of FOXA2 using Anti-FOXA2 Rabbit Polyclonal Antibody (Product # 720061, 1 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of FOXA2 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). Panel c) represents c... View More
Product Details
720061
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FOXA2 (aa 236-451)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 30% glycerol, 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
Target Information
FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin. They also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FKHL20; Forkhead box protein A2; hepatic nuclear factor-3-beta; Hepatocyte nuclear factor 3-beta; HNF-3-beta; MGC19807; RONU; TCF-3B; Transcription factor 3B; unnamed protein product; WHN
Gene Aliases: FOXA2; HNF-3-beta; HNF3B; TCF3B
UniProt ID: (Human) Q9Y261
Entrez Gene ID: (Human) 3170
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
nucleic acid binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
protein domain specific binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
cell fate specification
chromatin organization
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
adult locomotory behavior
anatomical structure morphogenesis
negative regulation of epithelial to mesenchymal transition
cell differentiation
regulation of blood coagulation
endocrine pancreas development
positive regulation of embryonic development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of insulin secretion involved in cellular response to glucose stimulus
response to interleukin-6
dopaminergic neuron differentiation
primitive streak formation
positive regulation of cell-cell adhesion mediated by cadherin
positive regulation of gastrulation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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