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Proteintech
FOXO3A Polyclonal Antibody
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产品信息
10849-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Pig,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
FOXO3A Fusion Protein Ag1289 (325-673 aa encoded by BC021224)
偶联物
形式
Liquid
浓度
0.35 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
The calculated molecular weight of FOXO3 is 71 kDa, but some experiments using a FOXO3a specific antibody showed the expression of a 90 kDa full-length FOXO3a protein (Full) and a 40 kDa processed FOXO3a product (Short).
Immunogen sequence: SPIMASTEL DEVQDDDAPL SPMLYSSSAS LSPSVSKPCT VELPRLTDMA GTMNLNDGLT ENLMDDLLDN ITLPPSQPSP TGGLMQRSSS FPYTTKGSGL GSPTSSFNST VFGPSSLNSL RQSPMQTIQE NKPATFSSMS HYGNQTLQDL LTSDSLSHSD VMMTQSDPLM SQASTAVSAQ NSRRNVMLRN DPMMSFAAQP NQGSLVNQNL LHHQHQTQGA LGGSRALSNS VSNMGLSESS SLGSAKHQQQ SPVSQSMQTL SDSLSGSSLY STSANLPVMG HEKFPSDLDL DMFNGSLECD MESIIRSELM DADGLDFNFD SLISTQNVVG LNVGNFTGAK QASSQSWVPG (325-673 aa encoded by BC021224)
靶标信息
USP48 is a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: AF6q21 protein; forkhead box O3A; Forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma-like 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
基因别名: 1110048B16Rik; 2010203A17Rik; AF6q21; C76856; Fkhr2; FKHRL1; FKHRL1P2; FOXO2; FOXO3; FOXO3A
UniProt ID: (Human) O43524, (Mouse) Q9WVH4
Entrez Gene ID: (Human) 2309, (Mouse) 56484, (Rat) 294515
core promoter binding
transcription cofactor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
protein kinase binding
chromatin DNA binding
sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
ovulation from ovarian follicle
initiation of primordial ovarian follicle growth
antral ovarian follicle growth
oocyte maturation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
regulation of translation
apoptotic process
anatomical structure morphogenesis
cell differentiation
DNA damage response, signal transduction by p53 class mediator
cellular response to oxidative stress
glucose homeostasis
positive regulation of neuron apoptotic process
positive regulation of erythrocyte differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of canonical Wnt signaling pathway
neuronal stem cell population maintenance
extrinsic apoptotic signaling pathway in absence of ligand
regulation of neural precursor cell proliferation
regulation of reactive oxygen species metabolic process
tumor necrosis factor-mediated signaling pathway
positive regulation of apoptotic process
