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Bethyl Laboratories
FOXO3a Polyclonal Antibody
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FOXO3a Antibody (A300-454A) in IHC (P)
Detection of human and mouse FOXO3a by immunohistochemistry. Sample: FFPE section of human ovarian carcinoma (left) and mouse renal cell carcinoma (right). Antibody: Affinity purified rabbit anti-FOXO3a (Product # A300-454A) (Lot 2) used at a dilution of 1:1,000 (1 µg/mL). Detection: DAB.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
A300-454A
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 625 and the C-terminus (residue 673) of human Forkhead Box O3a.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
tris citrate/phosphate, pH 7-8
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
靶标信息
USP48 is a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: forkhead box O3A; forkhead homolog (rhabdomyosarcoma) like 1; forkhead in rhabdomyosarcoma-like 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO3A-; member of FKHR-subclass forkhead/winged helix family; unnamed protein product
基因别名: 1110048B16Rik; 2010203A17Rik; AF6q21; Fkhr2; FKHRL1; FKHRL1P2; FOXO2; FOXO3A
UniProt ID: (Human) O43524, (Mouse) Q9WVH4
Entrez Gene ID: (Human) 2309, (Mouse) 56484
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
protein kinase binding
chromatin DNA binding
mitochondrial RNA polymerase binding promoter specificity activity
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
ovulation from ovarian follicle
initiation of primordial ovarian follicle growth
antral ovarian follicle growth
oocyte maturation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from mitochondrial promoter
regulation of translation
phagocytosis
response to xenobiotic stimulus
gene expression
positive regulation of autophagy
positive regulation of muscle atrophy
DNA damage response, signal transduction by p53 class mediator
negative regulation of cell migration
response to nutrient levels
tumor necrosis factor-mediated signaling pathway
cellular response to oxidative stress
cellular response to glucose starvation
glucose homeostasis
response to starvation
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of regulatory T cell differentiation
positive regulation of erythrocyte differentiation
negative regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
brain morphogenesis
response to fatty acid
cellular response to glucose stimulus
cellular response to corticosterone stimulus
response to dexamethasone
negative regulation of canonical Wnt signaling pathway
neuronal stem cell population maintenance
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of reactive oxygen species biosynthetic process
cellular response to beta-amyloid
cellular response to nerve growth factor stimulus
response to water-immersion restraint stress
regulation of neural precursor cell proliferation
positive regulation of endothelial cell apoptotic process
regulation of reactive oxygen species metabolic process
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