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Invitrogen
FOXP2 Polyclonal Antibody
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Product Details
PA5-17977
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (REIEEEPLSEDLE) corresponding to the C-terminus amino acids of FOXP2 (aa 703-715).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, canine, porcine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
FOXP2 is a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAG repeat protein 44; DKFZp686H1726; Forkhead box protein P2; forkhead/winged-helix transcription factor; OTTHUMP00000196932; trinucleotide repeat containing 10; Trinucleotide repeat-containing gene 10 protein
Gene Aliases: CAGH44; FOXP2; SPCH1; TNRC10
UniProt ID: (Human) O15409
Entrez Gene ID: (Human) 93986
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
sequence-specific DNA binding
metal ion binding
protein heterodimerization activity
negative regulation of transcription from RNA polymerase II promoter
positive regulation of mesenchymal cell proliferation
transcription, DNA-templated
skeletal muscle tissue development
post-embryonic development
cerebellum development
caudate nucleus development
putamen development
cerebral cortex development
growth
vocal learning
camera-type eye development
negative regulation of transcription, DNA-templated
lung alveolus development
smooth muscle tissue development
righting reflex
positive regulation of epithelial cell proliferation involved in lung morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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