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Agrisera
FTIP3/FTIP4/FT Interacting Protein 3/4 Polyclonal Antibody
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FTIP3/FTIP4/FT Interacting Protein 3/4 Antibody (AS23-5001) in WB
Samples: mctp 3 mctp 4 - Arabidopsis thaliana double knockout mutant mctp 3 - Arabidopsis thaliana single knockout mutant mctp 4 - Arabidopsis thaliana single knockout mutant Wild type - Arabidopsis thaliana wild type 10 µg od protein/well of total protein extracted freshly from 7 days old Arabidopsis thaliana seedlings. Exact buffer components were 150 m M Tris-HCl, p H 7.5; 150 m M Na Cl; 10% glycerol; 10... View More
产品信息
AS23-5001
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated peptide derived from Arabidopsis thaliana protein sequences of MCTP3 and MCTP4.
偶联物
形式
Lyophilized
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
靶标信息
FTIP3 and FTIP4 encode Arabidopsis multiple C2 domain and transmembrane region (MCTP)-type proteins that localize to endomembrane compartments and function in the shoot apical meristem (SAM) to control intracellular protein trafficking critical for stem cell maintenance. Structurally, both proteins are characterized by multiple N-terminal C2 domains (consistent with Ca2+-dependent membrane/lipid binding) coupled to C-terminal transmembrane region(s) that anchor them to membranes, supporting roles as membrane-tethered trafficking regulators rather than soluble transcriptional factors. Biologically, FTIP3/4 act to restrain aberrant delivery of the homeobox regulator SHOOTMERISTEMLESS (STM) to the plasma membrane in peripheral SAM cells, thereby favoring STM recycling/retention in the nucleus where it sustains meristematic identity; loss of FTIP3/4 shifts STM toward plasma-membrane accumulation, enhances intercellular trafficking at the expense of nuclear localization, and accelerates stem cell differentiation with premature shoot apex termination and dwarf, bushy architecture.
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生物信息学
蛋白别名: FTIP3; FTIP4; MCTP3; MCTP4
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