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Invitrogen
FTO Recombinant Rabbit Monoclonal Antibody (25GB3625)
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图: 1 / 4
FTO Antibody (MA570985) in ICC/IF
Immunocytochemistry analysis of FTO in HAP-1 cells. Sample was incubated with FTO monoclonal antibody (Product # MA570985) at a dilution of 1:1,000. Nuclei were stained blue with DAPI and Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA570985
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
25GB3625
抗原
A synthesized peptide derived from human (1-15) FTO.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Dry ice (international)
靶标信息
FTO is a novel protein and a member of the non-heme dioxygenase (Fe(II)-and 2-oxoglutarate-dependent dioxygenases) superfamily. Amino acid conservation patterns support this hypothesis and indicates that both 2-oxoglutarate and iron should be important for FTO function. Though not much is yet known about FTO, it is thought that the protein may somehow modify the activity of genes involved in metabolism and fat storage, which in turn may influence a person's risk of obesity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AlkB homolog 9; fat mass and obesity associated; fat mass and obesity-associated protein; fatso; intragenic FTO exon 9 containing transcript; m6A(m)-demethylase FTO; MGC5149; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; mRNA N(6)-methyladenine demethylase; mRNA N(6)-methyladenosine demethylase FTO; tRNA N1-methyl adenine demethylase FTO; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO; unnamed protein product
基因别名: ALKBH9; BMIQ14; GDFD; IFEX9
UniProt ID: (Human) Q9C0B1
Entrez Gene ID: (Human) 79068
protein binding
ferrous iron binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
oxidative RNA demethylase activity
oxidative DNA demethylase activity
RNA N6-methyladenosine dioxygenase activity
tRNA demethylase activity
temperature homeostasis
DNA dealkylation involved in DNA repair
regulation of lipid storage
snRNA processing
regulation of multicellular organism growth
RNA repair
regulation of respiratory system process
adipose tissue development
mRNA destabilization
regulation of white fat cell proliferation
regulation of brown fat cell differentiation
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
