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Invitrogen
FUSIP1 Polyclonal Antibody
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产品信息
PA5-41929
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the C-terminal of human FUSIP1 (aa 211-260).
偶联物
形式
Liquid
浓度
0.5 mg/mL
规格
50 µg
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Peptide sequence: TDSKTHYKSG SRYEKESRKK EPPRSKSQSR SQSRSRSKSR SRSWTSPKSS
Sequence homology: Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
靶标信息
SRSF10 (Serine and Arginine Rich Splicing Factor 10) is a member of the SR family of RNA-binding proteins that regulates alternative pre-mRNA splicing. It contains an RNA recognition motif (RRM) and a serine/arginine-rich (RS) domain that mediates RNA binding and protein-protein interactions within the spliceosome. SRSF10 functions as a context-dependent splicing regulator, capable of promoting or repressing exon inclusion depending on cellular conditions. Notably, it undergoes phosphorylation-dependent regulation, and during cellular stress or mitosis it can shift from an activator to a repressor of splicing. SRSF10 has been implicated in cell cycle control, apoptosis, metabolic regulation, and cancer-associated splicing alterations. Formerly known as FUSIP1 (FUS-interacting protein 1), SRSF10 is widely studied for its role in dynamic and stress-responsive RNA processing.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 40 kDa SR-repressor protein; contains RNP1 and RNP2 motifs; RS domain; FUS interacting protein (serine-arginine rich) 1; FUS-interacting protein (serine-arginine rich) 2; FUS-interacting serine-arginine-rich protein 1; FUSIP1; neural-salient SR protein; protein phosphatase 1, regulatory subunit 149; serine-arginine repressor protein (40 kDa); Serine/arginine-rich splicing factor 10; SFRS10; splicing factor; Splicing factor SRp38; splicing factor, arginine/serine-rich 13; Splicing factor, arginine/serine-rich 13A; SR protein; SR splicing factor 10; SRrp40; TASR; TLS-associated protein TASR; TLS-associated protein with Ser-Arg repeats; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein; TLS-associated serine-arginine protein 1; TLS-associated serine-arginine protein 2; TLS-associated SR protein; unnamed protein product
基因别名: FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13; SFRS13A; SRp38; SRrp40; SRSF10; TASR; TASR1; TASR2
UniProt ID: (Human) O75494
Entrez Gene ID: (Human) 10772
spliceosomal tri-snRNP complex assembly
RNA splicing, via transesterification reactions
regulation of alternative mRNA splicing, via spliceosome
mRNA splicing, via spliceosome
regulation of transcription, DNA-templated
mRNA splice site selection
mRNA processing
RNA splicing
cytosolic transport
regulation of mRNA splicing, via spliceosome
negative regulation of mRNA splicing, via spliceosome
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