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FYN Polyclonal Antibody, MaxPab™

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FYN Polyclonal Antibody, MaxPab™

产品信息

H00002534-D01P

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

Proximity Ligation Assay (PLA) (PLA)

1:1200
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

FYN (NP_002028.1, 1 a.a. approximately 537 a.a) full-length human protein.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

See Label

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Sequence of this protein is as follows: MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL

靶标信息

FYN is a SRC-related kinase expressed in brain, skeletal muscle and adipose tissues. Fyn functions in a large number of pathways and has been shown to play a role in memory. FYN is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: C syn protooncogene; c-syn protooncogene; EC 2.7.10.2; FYN oncogene related to SRC, FGR, YES; kinase Fyn; MGC45350; OKT3-induced calcium influx regulator; OTTHUMP00000017916; OTTHUMP00000017917; P59 p59-Fyn; p59-Fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; Protooncogene Syn; RP1-66H14.1; SLK; Src like kinase; Src-like kinase; src-like tyrosine kinase (put.); putative; src/yes-related novel; tyrosine kinase p59fyn(T); Tyrosine-protein kinase Fyn; unnamed protein product

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基因别名: FYN; p59-FYN; SLK; SYN

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UniProt ID: (Human) B5BU57

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Entrez Gene ID: (Human) 2534

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功能
nucleotide binding G-protein coupled receptor binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding tubulin binding phospholipase activator activity kinase activity transferase activity enzyme binding type 5 metabotropic glutamate receptor binding T cell receptor binding CD4 receptor binding CD8 receptor binding identical protein binding alpha-tubulin binding phospholipase binding phosphatidylinositol 3-kinase binding ion channel binding macromolecular complex binding metal ion binding ephrin receptor binding tau protein binding tau-protein kinase activity peptide hormone receptor binding growth factor receptor binding scaffold protein binding disordered domain specific binding
参与通路
response to singlet oxygen neuron migration stimulatory C-type lectin receptor signaling pathway adaptive immune response immune system process negative regulation of inflammatory response to antigenic stimulus heart process calcium ion transport cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled glutamate receptor signaling pathway axon guidance learning feeding behavior regulation of cell shape response to xenobiotic stimulus gene expression negative regulation of gene expression negative regulation of hydrogen peroxide biosynthetic process positive regulation of neuron projection development negative regulation of angiogenesis protein ubiquitination peptidyl-tyrosine phosphorylation layer formation in cerebral cortex natural killer cell activation cell differentiation protein catabolic process forebrain development neuron projection development T cell costimulation negative regulation of protein ubiquitination intracellular signal transduction cellular response to platelet-derived growth factor stimulus reelin-mediated signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis negative regulation of protein catabolic process response to cocaine proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of neuron apoptotic process response to ethanol vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway dendrite morphogenesis activated T cell proliferation modulation of synaptic transmission T cell receptor signaling pathway leukocyte migration detection of mechanical stimulus involved in sensory perception of pain positive regulation of protein kinase B signaling cellular response to hydrogen peroxide cellular response to growth factor stimulus cellular response to peptide hormone stimulus cellular response to transforming growth factor beta stimulus positive regulation of protein targeting to membrane dendritic spine maintenance positive regulation of protein localization to nucleus regulation of glutamate receptor signaling pathway negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of dendritic spine maintenance response to amyloid-beta cellular response to beta-amyloid cellular response to L-glutamate cellular response to glycine positive regulation of protein localization to membrane regulation of calcium ion import across plasma membrane regulation of neuron migration negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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