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Invitrogen
FZD7 Polyclonal Antibody
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FZD7 Antibody (PA5-47232) in IHC (F)
Immunohistochemical analysis of FZD7 in immersion fixed frozen sections of embryonic mouse gastrointestinal tract (11 d.p.c.). Samples were incubated in FZD7 polyclonal antibody (Product # PA5-47232) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue).
产品信息
PA5-47232
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant mouse Frizzled-7 Gln33-Leu185
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, approximately 15% cross-reactivity with recombinant mouse (rm) Frizzled-2 and less than 5% cross-reactivity with rmFrizzled-3, rmFrizzled-4, rhFrizzled-5, rmFrizzled-6, rmFrizzled-8, and rmFrizzled-9 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Frizzled-7; Fz-7; mFz7; rizzled 7
基因别名: Fz7; Fzd7
UniProt ID: (Mouse) Q61090
Entrez Gene ID: (Mouse) 14369
regulation of transcription, DNA-templated
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
multicellular organism development
negative regulation of cell-substrate adhesion
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
Wnt signaling pathway
stem cell population maintenance
T cell differentiation in thymus
substrate adhesion-dependent cell spreading
regulation of catenin import into nucleus
non-canonical Wnt signaling pathway
non-canonical Wnt signaling pathway via JNK cascade
positive regulation of phosphorylation
negative regulation of ectodermal cell fate specification
positive regulation of transcription, DNA-templated
somatic stem cell division
positive regulation of epithelial cell proliferation involved in wound healing
canonical Wnt signaling pathway
mesenchymal to epithelial transition
