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Invitrogen
Factor IX/Factor X (Emicizumab Biosimilar) Recombinant Humanized mouse Monoclonal Antibody
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Factor IX/Factor X (Emicizumab Biosimilar) Antibody (MA5-42074) in SDS-PAGE
SDS-PAGE analysis of the recombinant Human activated F10/F9 protein expressed in CHO cells using a Factor IX/Factor X (Emicizumab Biosimilar) monoclonal antibody (Product # MA5-42074). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
产品信息
MA5-42074
产品规格
种属反应
Human
宿主/亚型
Artificial Control
/ IgG4, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Human activated F10/F9
偶联物
形式
Liquid
浓度
1.1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
Coagulation factor IX is a single chain polypeptide with a molecular mass of 57 kDa. Normal concentrations of factor IX in human plasma is approximately 3 µg/mL. Factor IX deficiency and lack of coagulation activity is seen in patients suffering from the innate X-chromosome linked disorder, haemophilia B.
F10 undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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