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In direct ELISAs, less than 5% cross-reactivity with recombinant human (rh) Factor VII, rhFactor X, and rhFactor Xa is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in F7 production can cause coagulopathy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Coagulation factor VII; Factor 7; Factor7; Serum prothrombin conversion accelerator
基因别名: AI132620; Cf7; F7; FVII
UniProt ID: (Mouse) P70375
Entrez Gene ID: (Mouse) 14068
分子生物学功能: serine protease