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PA1-43061 detects Factor X in mouse samples.
PA1-43061 has successfully been used in Western blot and ELISA applications.
PA1-43061 was derived from mouse factor X.
Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Coagulation factor X; Stuart factor
基因别名: Cf10; F10; fX
UniProt ID: (Mouse) O88947
Entrez Gene ID: (Mouse) 14058
分子生物学功能: serine protease