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This antibody detects the heavy chains of human factor Xa and X; does not bind bovine factor X or BEGRck-Xa. Does not recognize murine or porcine X via Western blot. Inhibitory properties: inhibits PT, prothrombinase and partially APTT, but not amidase activity. Purity >95% by SDS-PAGE.
Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Coagulation factor X; factor Xa; prothrombinase; Stuart factor; Stuart-Prower factor
基因别名: F10; FX; FXA
UniProt ID: (Human) P00742
Entrez Gene ID: (Human) 2159
分子生物学功能:
serine protease