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Invitrogen
Factor X/Xa Monoclonal Antibody (5051)
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产品信息
MA1-43014
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Dog,
Human,
Sheep,
Pig,
Rabbit
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
5051
抗原
Purified bovine Factor X
偶联物
形式
Liquid
浓度
8.4 mg/mL
纯化类型
SDS-PAGE
保存液
50% water with 50% glycerol
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody detects the heavy chain of bovine Factor X and Xa, BEGRck factor Xa. It will cross-react with human, rabbit, sheep, porcine and canine factor X. This antibody does not recognize murine Factor X via Western blot. Inhibitory properties: inhibitory in clotting assay (APTT and PT), partial calcium dependence. Dissociation Constant: Kd = 9X10^(-11)M. Purity >95% by SDS-PAGE.
靶标信息
Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: blood coagulation factor X; Coagulation factor X; coagulation factor X protein; factor Xa; prothrombinase; Stuart factor; Stuart-Prower factor; unnamed protein product
基因别名: F10; FX; FXA
UniProt ID: (Rabbit) O19045, (Human) P00742, (Bovine) P00743
Entrez Gene ID: (Rabbit) 100008647, (Pig) 733662, (Dog) 476993, (Human) 2159, (Bovine) 280787, (Sheep) 101118624
