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Invitrogen
Farnesyl Polyclonal Antibody
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产品信息
PA1-12554
应用
建议稀释比
已发表文章
产品规格
种属反应
Chemical
已发表种属
Chemical
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Farnesyl cysteine conjugated to KLH
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
PBS
内含物
0.08% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Isoprenylation/methylation is an important posttranslational lipid modification: the covalent addition of a 15 carbon farnesyl or a 20-carbon geranylgeranyl group to the C-terminus of a protein results in a substantial increase in hydrophobicity. All known G proteins are modified in this way, making the pathway of central interest for an understanding of signal transduction. From nematode to human, many eukaryotic proteins are reported to be isoprenylated. Known prenylated prtoteins include fungal mating factors, nuclear lamins, Ras and Ras-related GTP-binding proteins (G proteins), and the subunits of trimeric G proteins, protein kinases and at least one viral prtoein. Prenylation promotes membrane interactions of most of these proteins, which is not surprising given the hydrophobicity of the lipids involved. In addition, prenylation appears to play a major role in several protein-protein interaction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
