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Invitrogen
Fe65 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-46191
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant rat FE65, expressed in bacteria.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.3 mg/mL
Amount
130 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 15% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: IMR32 neuronal cell lysate, HEK 293 cell lysate, or brain lysate, antigen standard for APBB1 (transient overexpression lysate).
Target Information
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein, transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: amyloid beta A4 precursor protein-binding family B member 1; Amyloid beta precursor protein binding family B member 1; Amyloid-beta A4 precursor protein-binding family B member 1; Protein Fe65
Gene Aliases: APBB1; FE65; RIR
UniProt ID: (Rat) P46933, (Mouse) Q9QXJ1
Entrez Gene ID: (Rat) 29722, (Mouse) 11785
neuron migration
double-strand break repair
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
cellular response to DNA damage stimulus
cell cycle arrest
axon guidance
visual learning
response to iron ion
extracellular matrix organization
negative regulation of cell growth
positive regulation of apoptotic process
histone H4 acetylation
negative regulation of neuron differentiation
positive regulation of DNA repair
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein secretion
negative regulation of thymidylate synthase biosynthetic process
chromatin modification
actin filament-based movement
protein stabilization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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