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Invitrogen
Felzartamab Recombinant Human Monoclonal Antibody
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产品信息
MA5-59211
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Felzartamab is a fully human recombinant immunoglobulin G1 (IgG1) monoclonal antibody (mAb) that targets CD38 on plasma cells. CD38 is a multifunctional enzyme that is widely expressed in both immune and non-hematopoietic cells. It plays a critical role in NAD+ metabolism by converting NAD+ to ADP-ribose and nicotinamide, which are key molecules in cellular signaling and energy metabolism. Structurally, CD38 is a transmembrane glycoprotein with ectoenzyme activity, meaning that its enzymatic functions occur on the outer surface of the cell membrane. CD38's activity is particularly significant in aging, as its expression increases in immune cells due to the senescence-associated secretory phenotype. This elevation in CD38 activity contributes to decreased NAD+ levels, which is associated with various age-related diseases. CD38 has also been identified as a potential therapeutic target for conditions such as renal immune diseases and age-related metabolic decline.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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