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Invitrogen
Fibrillarin/FBLL1 Recombinant Rabbit Monoclonal Antibody (HL2588)
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图: 1 / 5
Fibrillarin/FBLL1 Antibody (MA5-56708) in ICC/IF
Immunocytochemistry analysis of Fibrillarin/FBLL1 using Fibrillarin/FBLL1 Recombinant Monoclonal Antibody (Product # MA5-56708) in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Fibrillarin/FBLL1 antibody diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody (Product # MA5-31466) Blue: Fluoroshield with DAPI.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-56708
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2588
抗原
Recombinant fragment of human fibrillarin.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
Fibrillarin, encoded by the FBL gene (also known as FBLL1), is a highly conserved nucleolar protein that plays a critical role in the biogenesis of ribosomes. It is a component of the small nucleolar ribonucleoprotein (snoRNP) complexes and is primarily involved in the chemical modification of ribosomal RNA (rRNA), specifically in the methylation of the 2'-O-ribose residues of rRNA. This modification is essential for the proper processing and maturation of pre-rRNA into functional ribosomal subunits, which are crucial for protein synthesis within the cell. Fibrillarin is not only important for ribosome production but also for maintaining the structural integrity of the nucleolus, the site of ribosome assembly. Dysregulation or mutations in the FBL gene have been associated with various human diseases, including cancer, where altered ribosome biogenesis can contribute to uncontrolled cell proliferation. Additionally, fibrillarin has been studied in the context of autoimmune diseases, such as systemic sclerosis, where it can serve as an autoantigen. Understanding the function and regulation of fibrillarin is vital for insights into cellular growth, protein synthesis, and the pathogenesis of related diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 34 kDa nucleolar scleroderma antigen; Fibrillarin like 1; Histone-glutamine methyltransferase; Nucleolar protein 1; protein-glutamine methyltransferase; RNA 2'-O-methyltransferase FBLL1; rRNA 2'-O-methyltransferase fibrillarin; rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; U6 snRNA 2'-O-methyltransferase fibrillarin
基因别名: AI595406; AL022665; FBL; FBLL1; FIB; FIB1; FLRN; RGD1562841; RNU3IP1
UniProt ID: (Rat) P22509, (Mouse) Q99L58, (Mouse) Q80WS3
Entrez Gene ID: (Rat) 292747, (Mouse) 14113, (Mouse) 237730, (Rat) 363563
RNA binding
poly(A) RNA binding
histone-glutamine methyltransferase activity
rRNA (adenine-N6,N6-)-dimethyltransferase activity
protein C-terminal carboxyl O-methyltransferase activity
tRNA (guanine-N2-)-methyltransferase activity
methyltransferase activity
C-methyltransferase activity
N-methyltransferase activity
O-methyltransferase activity
S-methyltransferase activity
RNA methyltransferase activity
mRNA methyltransferase activity
tRNA methyltransferase activity
protein methyltransferase activity
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
rRNA methyltransferase activity
rRNA (uridine-2'-O-)-methyltransferase activity
rRNA (adenine-N6-)-methyltransferase activity
DNA-methyltransferase activity
tRNA (guanine-N1-)-methyltransferase activity
rRNA (cytosine-C5-)-methyltransferase activity
selenocysteine methyltransferase activity
arginine N-methyltransferase activity
protein-arginine N-methyltransferase activity
lysine N-methyltransferase activity
protein-lysine N-methyltransferase activity
tRNA (uracil) methyltransferase activity
tRNA (guanine) methyltransferase activity
tRNA (adenine) methyltransferase activity
tRNA (cytosine) methyltransferase activity
tRNA (cytosine-5-)-methyltransferase activity
tRNA (adenine-N1-)-methyltransferase activity
rRNA (adenine) methyltransferase activity
rRNA (cytosine) methyltransferase activity
rRNA (guanine) methyltransferase activity
rRNA (uridine) methyltransferase activity
transferase activity
protein C-terminal leucine carboxyl O-methyltransferase activity
1-phenanthrol methyltransferase activity
protein-arginine N5-methyltransferase activity
methylarsonite methyltransferase activity
dimethylarsinite methyltransferase activity
4,5-dihydroxybenzo(a)pyrene methyltransferase activity
1-hydroxypyrene methyltransferase activity
1-hydroxy-6-methoxypyrene methyltransferase activity
demethylmenaquinone methyltransferase activity
cobalt-precorrin-6B C5-methyltransferase activity
cobalt-precorrin-7 C15-methyltransferase activity
cobalt-precorrin-5B C1-methyltransferase activity
cobalt-precorrin-3 C17-methyltransferase activity
dimethylamine methyltransferase activity
hydroxyneurosporene-O-methyltransferase activity
tRNA (adenine-57, 58-N(1)-) methyltransferase activity
methylamine-specific methylcobalamin:coenzyme M methyltransferase activity
trimethylamine methyltransferase activity
methanol-specific methylcobalamin:coenzyme M methyltransferase activity
monomethylamine methyltransferase activity
P-methyltransferase activity
Se-methyltransferase activity
2-phytyl-1,4-naphthoquinone methyltransferase activity
tRNA (uracil-2'-O-)-methyltransferase activity
tRNA (cytosine-2'-O-)-methyltransferase activity
phosphomethylethanolamine N-methyltransferase activity
tRNA (cytosine-3-)-methyltransferase activity
rRNA (cytosine-2'-O-)-methyltransferase activity
rRNA (cytosine-N4-)-methyltransferase activity
trihydroxyferuloyl spermidine O-methyltransferase activity
RNA processing factor
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